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Home / Primary Antibodies / Polyclonal Antibodies

p38a Antibody (pThr180+pTyr182) - SPC-1037

BHA11913482
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Ask Merchant
Request More Infos
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Swissprot Q16539
Accession Number NP_620581
Gene Id 1432
Target p38a (pThr180+pTyr182)
Research Area Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, MAPK Pathway, Immunology, Innate Immunity, TLR Signaling
Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions WB (1:250); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Purity Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney
Scientific Background MAPK14 is a protein-serine/threonine kinase that is activated by pro-inflammatory cytokines, environmental stress and LPS, via phosphorylation by MAP kinase kinases, or autophosphorylation. Its substrates include the transcription regulators ATF2, MEF2C, and MAX; the cell cycle regulator CDC25B; and p53, which indicates that MAPK14 plays a role in stress-related transcription and in cell cycle regulation, as well as in the genotoxic stress response. It is a key player in the maintenance of hematopoiesis homeostasis, as it balances both proliferative and growth inhibitory signals from growth factors/cytokines that regulate hematopoiesis. Alterations in this controlled balance could result in either overproduction or depletion of myelosuppressive cytokines, which could lead to the development of various types of bone marrow failures.
Shipping Temperature Blue Ice or 4°C
Specificity Detects 41.293 kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, WB
Description WB ; AM
Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11913482-1 SPC-1037D Unconjugated 100 ul $331
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BHA11913482-2 SPC-1037D-A390 ATTO 390 100 ul $385
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BHA11913482-3 SPC-1037D-A488 ATTO 488 100 ul $384
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BHA11913482-4 SPC-1037D-A594 ATTO 594 100 ul $384
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BHA11913482-5 SPC-1037D-BI Biotin 100 ul $380
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BHA11913482-6 SPC-1037D-FITC FITC 100 ul $375
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