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Home / Primary Antibodies

NTRK1 (Ab-791) Antibody

SKU : BHA10557493

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA217013
Alternative Names	High affinity nerve growth factor receptor precursor; NTRK1; Slow nerve growth factor receptor; TRK; TRK1 transforming tyrosine kinase protein
Categories	Primary Antibodies
Clonality	polyclonal
Description	Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.Wiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17210-5.Valdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12270-5Inoue K, et al. J Biol Chem. 2007 Aug 17;282(33):24175-84
Host	Rabbit
Immunogen	Peptide sequence around aa.789~793 (P-V-Y-L-D) derived from Human TrkA.
Involvement In Disease	Congenital insensitivity to pain with anhidrosis (CIPA)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Wiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17210-5. Valdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12270-5 Inoue K, et al. J Biol Chem. 2007 Aug 17;282(33):24175-84
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total TrkA protein.
Subcellular Location	Cell membrane, Single-pass type I membrane protein, Early endosome membrane, Single-pass type I membrane protein, Late endosome membrane, Single-pass type I membrane protein

Uniprot	P04629
Database Links	HGNC:8031 OMIM:164970 KEGG:hsa:4914 STRING:9606.ENSP00000431418 UniGene:Hs.406293
Function	Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand
Pathway	MAPK signaling pathway PI3K-Akt signaling pathway Apoptosis Ras signaling pathway Inflammatory Pain Neurotrophin signaling pathway
Protein Families	Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Tissue Specificity	Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IF

Description

ELISA ; IF, IF ; ELISA

Dilution

IF	1:100-1:200

Tested Application

ELISA,IF;IF:1:100-1:200

Datasheet
ELISA Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557493	CSB-PA217013	100ul	$297		Add to Cart

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