Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.Geller D.A., Proc. Natl. Acad. Sci. U.S.A. 90:3491-3495(1993).Sherman P.A., Biochemistry 32:11600-11605(1993).Charles I.G., Proc. Natl. Acad. Sci. U.S.A. 90:11419-11423(1993)
Host
Rabbit
Immunogen
Synthesized non-phosphopeptide derived from Human iNOS around the phosphorylation site of tyrosine 151 (Q-Y-Y(p)-G-S).
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
Geller D.A., Proc. Natl. Acad. Sci. U.S.A. 90:3491-3495(1993). Sherman P.A., Biochemistry 32:11600-11605(1993). Charles I.G., Proc. Natl. Acad. Sci. U.S.A. 90:11419-11423(1993)
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total iNOS protein.