Treg activation is critical for maintaining self-tolerance, but the translational control of this process is still poorly understood. Zhu et al. report a conserved ribosome biogenesis factor, Noc4L, that regulates mRNAs related to Treg and Tconv activation but does not affect global protein translation. Noc4L regulates translation of mRNAs related to Treg activation. Noc4L plays critical roles in activation of Tregs and Tconvs. Noc4L-mediated ribosome biogenesis is critical in controlling the activation of Tregs and maintaining immune tolerance. (Zhu et al., 2019, Cell Reports 27, 1205 1220.)
Formulation
1 mg/ml in 1X PBS; BSA free, sodium azide free
Host
Mouse
Immunogen Region
Recombinant full-length human NOC4L protein was used as the immunogen for the NOC4L antibody.
Isotype
Mouse IgG1
Species Reactivity
Human
Note
Optimal dilution of the NOC4L antibody should be determined by the researcher.
Uniprot
Q9BVI4
Format
Purified
Purity
Protein A/G affinity
Storage
Aliquot the NOC4L antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.