Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (. Exhibits histidine protein kinase activity.G Scambia, J. Clin. Oncol., Feb 1996; 14: 334 - 342. S Kapitanovic, J. Clin. Pathol., Dec 2004; 57: 1312 - 1318. R Amendola, J Natl Cancer Inst, Sep 1997; 89: 1300 - 1310. Norio Iizuka, Cancer Res., Feb 1995; 55: 652 - 657.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human NM23.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (. Exhibits histidine protein kinase activity.
G Scambia, J. Clin. Oncol., Feb 1996; 14: 334 - 342. S Kapitanovic, J. Clin. Pathol., Dec 2004; 57: 1312 - 1318. R Amendola, J Natl Cancer Inst, Sep 1997; 89: 1300 - 1310. Norio Iizuka, Cancer Res., Feb 1995; 55: 652 - 657.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total NM23 protein.
Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically
Protein Families
NDK family
Tissue Specificity
Isoform 1 and isoform 3 are ubiquitously expressed.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.