NMDAR2C, known as GRIN2C, is mapped to 17q25.1. Glutamate (NMDA) receptor subunit epsilon-3 is a protein that in humans is encoded by the GRIN2C gene. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as leaing, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alteative splicing results in multiple transcript variants.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
Amino acids 43-242 of human NMDAR2C were used as the immunogen for the NMDAR2C antibody.
Isotype
IgG
Predicted Reactivity
Human, Rat
Reactivity
Human, Rat
Recombinant
No
Uniprot
Q14957
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the NMDAR2C antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.