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Home / Primary Antibodies / Polyclonal Antibodies

NHE3 Antibody - SPC-400

BHA11907748
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+1 866.986.9598
Email
[email protected]
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Swissprot P26433
Accession Number NP_036786
Gene Id 24784
Target NHE3
Research Area Cell Signaling, Pumps/Transporters, Cancer, Ion Pumps/Transporters, Neuroscience
Buffer PBS, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000); optimal dilutions for assays should be determined by the user.
Purification Protein A Purified
Purity Most abundant in colon and small intestine, followed by kidney and stomach. In kidney, expressed in proximal tubules and outer medulla (at protein level)
Scientific Background Sodium-hydrogen exchanger 3 (NHE3; Slc9a3) is an epithelial transport protein that carries out 1:1 exchange of Na+ and H+ across the plasma membrane. It is apically located in the proximal tubule of the kidney, the thick ascending limb of the kidney, and in small intestine (1). NHE3 is phosphorylated and regulated by multiple kinases including PKA, SGK1 and CK2. It can be phosphorylated by calyculin A, and dephosphorylated by PP1 catalytic subunit in vitro (2).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~84kDa.
Storage -20ºC
Storage Buffer PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IHC, WB, ICC/IF
Description WB ; ICC ; IF
Dilution WB (1:1000); IHC (1:25); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Kim G.H., Ecelbarger C.A., Knepper M.A. and Packer R.K. (1999) J Am Soc Nephrol. 10: 935-942.

2. Dynia D.W., Steinmetz A.G. and Kocinsky H.S. (2010) Am J Physoil Renal Physiol. 298(3): F745-F753.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11907748-1 SPC-400D Unconjugated 100 ug $341
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BHA11907748-2 SPC-400D-A390 ATTO 390 100 ug $395
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BHA11907748-3 SPC-400D-A488 ATTO 488 100 ug $394
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BHA11907748-4 SPC-400D-A594 ATTO 594 100 ug $394
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BHA11907748-5 SPC-400D-ALP Alkaline Phosphatase 100 ug $387
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BHA11907748-6 SPC-400D-APC APC 100 ug $393
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BHA11907748-7 SPC-400D-BI Biotin 100 ug $389
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BHA11907748-8 SPC-400D-FITC FITC 100 ug $385
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BHA11907748-9 SPC-400D-HRP HRP 100 ug $381
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BHA11907748-10 SPC-400D-PCP PerCP 100 ug $393
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BHA11907748-11 SPC-400D-RPE RPE 100 ug $391
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BHA11907748-12 SPC-400S Unconjugated 12 ug $44
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