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Home / Antibodies

NGFR Antibody

SKU : BHA10559266

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA038076
Alternative Names	Gp80-LNGFR; NGF receptor; TNFRSF16; TNR16; low affinity neurotrophin receptor p75NTR
Categories	Primary Antibodies
Clonality	polyclonal
Description	Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake By similarity. Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.Ye X., J. Biol. Chem. 274:30202-30208(1999).Wooten M.W., J. Biol. Chem. 276:7709-7712(2001).Bai D., Biochem. Biophys. Res. Commun. 309:552-557(2003).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human TNR16.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake By similarity. Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. Ye X., J. Biol. Chem. 274:30202-30208(1999). Wooten M.W., J. Biol. Chem. 276:7709-7712(2001). Bai D., Biochem. Biophys. Res. Commun. 309:552-557(2003).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TNR16 protein.
Subcellular Location	Membrane, Single-pass type I membrane protein

Uniprot	P08138
Database Links	HGNC:7809 OMIM:162010 KEGG:hsa:4804 STRING:9606.ENSP00000172229 UniGene:Hs.415768
Function	Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.
Pathway	MAPK signaling pathway PI3K-Akt signaling pathway Ras signaling pathway Rap1 signaling pathway Neurotrophin signaling pathway

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559266	CSB-PA038076	100ul	$297		Add to Cart

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