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NFKBIA Antibody

SKU : BHA10557831

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA125146
Alternative Names	I-kappa-B-alpha; IkappaBalpha; IKBA; MAD3; Major histocompatibility complex enhancer-binding protein MAD3
Categories	Primary Antibodies
Clonality	polyclonal
Description	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.Haskill S., Cell 65:1281-1289(1991).Jungnickel B., J. Exp. Med. 191:395-402(2000).Liu B., Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
Host	Rabbit
Immunogen	Synthesized peptide derived from N-terminal of Human IκB-α.
Involvement In Disease	Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency autosomal dominant (ADEDAID)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. Haskill S., Cell 65:1281-1289(1991). Jungnickel B., J. Exp. Med. 191:395-402(2000). Liu B., Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total IκB-α protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	P25963
Database Links	HGNC:7797 OMIM:164008 KEGG:hsa:4792 STRING:9606.ENSP00000216797 UniGene:Hs.81328
Function	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Pathway	cAMP signaling pathway Chemokine signaling pathway NF-kappa B signaling pathway TNF signaling pathway Apoptosis B cell receptor signaling pathway IL-17 signaling pathway Inflammasome Signaling NOD-like receptor signaling pathway Osteoclast differentiation T cell receptor signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Toll-like receptor signaling pathway Adipocytokine signaling pathway Neurotrophin signaling pathway
Protein Families	NF-kappa-B inhibitor family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557831	CSB-PA125146	100ul	$297		Add to Cart

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