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Home / Primary Antibodies

NF2 Antibody

SKU : BHA10557403

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA249373
Alternative Names	MERL; moesin-ezrin-radizin-like protein; neurofibromatosis type 2 gene; neurofibromatosis-2; Neurofibromin 2; NF-2; NF2; SCH; Schwannomerlin; schwannomerlin; Schwannomin
Categories	Primary Antibodies
Clonality	polyclonal
Description	This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport."
Host	Rabbit
Immunogen	A synthesized peptide derived from Human Merlin
Involvement In Disease	Neurofibromatosis 2 (NF2); Schwannomatosis 1 (SWNTS1); Mesothelioma, malignant (MESOM)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. "
Species	Homo Sapiens (Human)
Specificity	Merlin Antibody detects endogenous levels of total Merlin
Subcellular Location	Isoform 1: Cell projection, filopodium membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, ruffle membrane, Peripheral membrane protein, Cytoplasmic side, Nucleus, Note=In a fibroblastic cell line, isoform 1 is found homogeneously distributed over the entire cell, with a particularly strong staining in ruffling membranes and filopodia, Colocalizes with MPP1 in non-myelin-forming Schwann cells, Binds with DCAF1 in the nucleus, The intramolecular association of the FERM domain with the C-terminal tail promotes nuclear accumulation, The unphosphorylated form accumulates predominantly in the nucleus while the phosphorylated form is largely confined to the non-nuclear fractions, SUBCELLULAR LOCATION: Isoform 7: Cytoplasm, perinuclear region, Cytoplasmic granule, Note=Observed in cytoplasmic granules concentrated in a perinuclear location, Isoform 7 is absent from ruffling membranes and filopodia, SUBCELLULAR LOCATION: Isoform 9: Cytoplasm, perinuclear region, Cytoplasmic granule, Note=Observed in cytoplasmic granules concentrated in a perinuclear location, Isoform 9 is absent from ruffling membranes and filopodia, SUBCELLULAR LOCATION: Isoform 10: Nucleus, Cell projection, filopodium membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, ruffle membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasm, perinuclear region, Cytoplasmic granule, Cytoplasm, cytoskeleton

Uniprot	P35240
Database Links	HGNC:7773 OMIM:101000 KEGG:hsa:4771 STRING:9606.ENSP00000344666 UniGene:Hs.187898
Function	Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
Pathway	Hippo signaling pathway
Tissue Specificity	Widely expressed. Isoform 1 and isoform 3 are predominant. Isoform 4, isoform 5 and isoform 6 are expressed moderately. Isoform 8 is found at low frequency. Isoform 7, isoform 9 and isoform 10 are not expressed in adult tissues, with the exception of adul

Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antigen Affinity Purified
Purity	Antigen Affinity Purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:2000

Tested Application

ELISA,WB;WB:1:500-1:2000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557403	CSB-PA249373	100ul	$295		Add to Cart

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