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Home / Primary Antibodies

NEUROD1 (Ab-274) Antibody

SKU : BHA10557702

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA054941
Alternative Names	Neurogenic differentiation factor 1; NEUROD1; NEUROD;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis By similarity.Tamimi R., Genomics 34:418-421(1996).Yokoyama M., Brain Res. Mol. Brain Res. 42:135-139(1996).Miyachi T., Brain Res. Mol. Brain Res. 69:223-231(1999)
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human Neuro D around the phosphorylation site of serine 272 (P-L-S(p)-P-P-).
Involvement In Disease	Maturity-onset diabetes of the young 6 (MODY6); Diabetes mellitus, non-insulin-dependent (NIDDM)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis By similarity. Tamimi R., Genomics 34:418-421(1996). Yokoyama M., Brain Res. Mol. Brain Res. 42:135-139(1996). Miyachi T., Brain Res. Mol. Brain Res. 69:223-231(1999)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Neuro D protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	Q13562
Database Links	HGNC:7762 OMIM:125853 KEGG:hsa:4760 STRING:9606.ENSP00000295108 UniGene:Hs.574626
Function	Acts as a transcriptional activator

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557702	CSB-PA054941	100ul	$297		Add to Cart

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