Mouse Anti-Human Nav1.7 Monoclonal IgG1

Mfr.No.	SMC-314, SMC-314D, SMC-314D-A390, SMC-314D-A488, SMC-314D-A594, SMC-314D-ALP, SMC-314D-APC, SMC-314D-BI, SMC-314D-FITC, SMC-314D-HRP, SMC-314D-PCP, SMC-314D-RPE, SMC-314S
Immunogen Species	Human
Alternative Names	ETHA Antibody, hNE Na Antibody, NE NA Antibody, PN1 Antibody, SCN9A Antibody, voltage gated sodium channel subunit alpha Nav1 Antibody, peripheral sodium channel 1 Antibody, neuroendocrine sodium channel Antibody
Antigen	Nav1.7
Categories	Antibodies
Cellular Localization	Membrane, Synapse
Certificate Of Analysis	1 ug/ml of SMC-314 was sufficient for detection of Nav1.7 in 10 ug of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Conjugate	Unconjugated, ATTO 390, ATTO 488, ATTO 594, Alkaline Phosphatase, APC, Biotin, FITC, HRP, PerCP, RPE
Description	Mouse Anti-Human Nav1.7 Monoclonal IgG1
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7, Homo Sapiens (Human)
Immunogen Region	Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7
Isotype	IgG1
Launch Date	2009/07/06
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human, Hamster
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Rat, Hamster, Human

Swissprot	Q15858
Accession Number	NP_002968.1
Gene Id	6335
Target	Nav1.7
Clone No	N68/6
Research Area	Ion Channels, Sodium Channels, Voltage-Gated Sodium Channels, Cancer, Cell Signaling, Neuroscience

Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals (1-3).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~230kDa. No cross-reactivity against other Nav channels.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, IP, WB, IHC, ICC/IF
Description	WB ; ICC ; IF ; IP ; AM
Dilution	WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Dray A. (2008) Br. J. Anaesth. 101(1): 48-58. 2. Dray A., Read S.J (2007) Arthritis Res. Ther. 9(3): 212. 3. Samuels M.E., teMorshe R.H., Lynch M.E., Drenth J.P. (2008) Mol Pain. 4: 21.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11902709-1	SMC-314D	Unconjugated	100 ug	$330	Add to Cart
BHA11902709-2	SMC-314D-A390	ATTO 390	100 ug	$384	Add to Cart
BHA11902709-3	SMC-314D-A488	ATTO 488	100 ug	$383	Add to Cart
BHA11902709-4	SMC-314D-A594	ATTO 594	100 ug	$383	Add to Cart
BHA11902709-5	SMC-314D-ALP	Alkaline Phosphatase	100 ug	$376	Add to Cart
BHA11902709-6	SMC-314D-APC	APC	100 ug	$382	Add to Cart
BHA11902709-7	SMC-314D-BI	Biotin	100 ug	$378	Add to Cart
BHA11902709-8	SMC-314D-FITC	FITC	100 ug	$374	Add to Cart
BHA11902709-9	SMC-314D-HRP	HRP	100 ug	$370	Add to Cart
BHA11902709-10	SMC-314D-PCP	PerCP	100 ug	$382	Add to Cart
BHA11902709-11	SMC-314D-RPE	RPE	100 ug	$380	Add to Cart
BHA11902709-12	SMC-314S	Unconjugated	12 ug	$44	Add to Cart

Nav1.7 Antibody, Clone N68/6 - SMC-314