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Home / Primary Antibodies

MSX2 Antibody

SKU : BHA10558451

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA030362
Alternative Names	CRS2; FPP; Homeobox protein Hox-8; Homeobox protein MSX-2; HOX8
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.Hodgkinson J.E., Biochim. Biophys. Acta 1174:11-16(1993).Jabs E.W., Cell 75:443-450(1993).Iimura T., DNA Seq. 8:87-92(1997).
Host	Rabbit
Immunogen	Synthesized peptide derived from Internal of Human MSX2.
Involvement In Disease	Parietal foramina 1 (PFM1); Parietal foramina with cleidocranial dysplasia (PFMCCD); Craniosynostosis 2 (CRS2)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. Hodgkinson J.E., Biochim. Biophys. Acta 1174:11-16(1993). Jabs E.W., Cell 75:443-450(1993). Iimura T., DNA Seq. 8:87-92(1997).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MSX2protein.
Subcellular Location	Nucleus

Uniprot	P35548
Database Links	HGNC:7392 OMIM:123101 KEGG:hsa:4488 STRING:9606.ENSP00000239243 UniGene:Hs.89404
Function	Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.
Protein Families	Msh homeobox family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558451	CSB-PA030362	100ul	$297		Add to Cart

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