JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.
Loding Loading ....
Home / Primary Antibodies / Polyclonal Antibodies

MSK1 Antibody (pSer212) - SPC-1031

BHA11913374
Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Request More Infos
Order Now

Credit card payments now incur a 3% fee.

Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Ask Merchant
Request More Infos
Sample Request
Swissprot O75582
Accession Number NP_004746
Gene Id 9252
Target MSK1 (pSer212)
Research Area Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, Tyrosine Kinases, Receptor Tyrosine Kinases, Epigenetics and Nuclear Signaling, Transcription, Metabolism, Redox Metabolism, Metabolism and Oxidative Stress
Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions WB (1:250); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Purity Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.
Scientific Background Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumour formation. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury.
Shipping Temperature Blue Ice or 4°C
Specificity Detects 89.865 kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, WB
Description WB ; AM
Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11913374-1 SPC-1031D Unconjugated 100 ul $331
Add to Cart
BHA11913374-2 SPC-1031D-A390 ATTO 390 100 ul $385
Add to Cart
BHA11913374-3 SPC-1031D-A488 ATTO 488 100 ul $384
Add to Cart
BHA11913374-4 SPC-1031D-A594 ATTO 594 100 ul $384
Add to Cart
BHA11913374-5 SPC-1031D-BI Biotin 100 ul $380
Add to Cart
BHA11913374-6 SPC-1031D-FITC FITC 100 ul $375
Add to Cart