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Home / Antibodies

MRP4 Antibody (R31565)

SKU : BHA17104948

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Mfr.No.	R31565
Clonality	Polyclonal
Description	ABCC4 (ATP-binding cassette, subfamily c, member 4) also known as MRP4 (Multidrug resistance associated protein 4) or MOATB, is a protein that in humans is encoded by the ABCC4 gene. It belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. This gene is mapped to chromosome 13q32. ABCC4/MRP4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of MPR4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of its activity or knockdown of the protein via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. It has been found that MRP4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	Human partial recombinant protein (AA 1-370) was used as the immunogen for this MRP4 antibody.
Isotype	IgG
Predicted Reactivity	Human, Mouse, Rat
Reactivity	Human, Mouse, Rat
Recombinant	No

Gene Id	10257

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	The lyophilized MRP4 antibody can be stored at 4°C to -20°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB, IHC-P
Dilution	Weste blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104948	R31565	100 ug	$419		Add to Cart

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