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Home / Antibodies

MRE11A Antibody

SKU : BHA10558145

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA584586
Alternative Names	Double-strand break repair protein MRE11A; MRE11 homolog 1; MRE11 meiotic recombination 11 homolog A; MRE11A; HNGS1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.Petrini J.H.J.,, Genomics 29:80-86(1995).Paull T.T., Mol. Cell 1:969-979(1998).Pitts S.A., Hum. Mol. Genet. 10:1155-1162(2001).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human MRE11A.
Involvement In Disease	Ataxia-telangiectasia-like disorder 1 (ATLD1)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. Petrini J.H.J.,, Genomics 29:80-86(1995). Paull T.T., Mol. Cell 1:969-979(1998). Pitts S.A., Hum. Mol. Genet. 10:1155-1162(2001).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MRE11A protein.
Subcellular Location	Nucleus, Chromosome, telomere

Uniprot	P49959
Database Links	HGNC:7230 OMIM:600814 KEGG:hsa:4361 STRING:9606.ENSP00000325863 UniGene:Hs.192649
Function	Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point
Pathway	Cellular senescence
Protein Families	MRE11/RAD32 family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558145	CSB-PA584586	100ul	$297		Add to Cart

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