Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.Taylor M.E., J. Biol. Chem. 265:12156-12162(1990).Ezekowitz R.A., J. Exp. Med. 172:1785-1794(1990).Kim S.J., Genomics 14:721-727(1992).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human MRC1.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.
Taylor M.E., J. Biol. Chem. 265:12156-12162(1990). Ezekowitz R.A., J. Exp. Med. 172:1785-1794(1990). Kim S.J., Genomics 14:721-727(1992).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total MRC1 protein.
Subcellular Location
Endosome membrane, Single-pass type I membrane protein, Cell membrane, Single-pass type I membrane protein