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Home / Antibodies

MNAT1 Antibody

SKU : BHA10557870

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA583349
Alternative Names	AMS1; AdoMet synthetase; EC 2.5.1.6; MAT-I/III; MATA1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.Tassan J.-P., EMBO J. 14:5608-5617(1995).Yee A., Cancer Res. 55:6058-6062(1995).Tirode F., Mol. Cell 3:87-95(1999).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human MAT1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Tassan J.-P., EMBO J. 14:5608-5617(1995). Yee A., Cancer Res. 55:6058-6062(1995). Tirode F., Mol. Cell 3:87-95(1999).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MAT1 protein.
Subcellular Location	Nucleus

Uniprot	P51948
Database Links	HGNC:7181 OMIM:602659 KEGG:hsa:4331 STRING:9606.ENSP00000261245 UniGene:Hs.509523
Function	Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
Pathway	DNA repair pathway
Tissue Specificity	Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557870	CSB-PA583349	100ul	$297		Add to Cart

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