May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
Host
Rabbit
Immunogen
Peptide sequence around aa.110-114(F-E-G-D-L) derived from Human MMP-9.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- ; -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous level of total MMP-9 protein.