Matrix metalloproteinase-7, previously called putative metalloproteinase I (PUMP1) or Matrilysin has been identified through studies of collagenase-related connective-tissue-degrading metalloproteinases produced by human tumors. The MMP7 protein has 267 amino acids and is significantly shorter than stromelysin or collagenase (477 and 469 amino acids, respectively). Matrix metalloproteinases play a crucial role in tumor invasion and metastasis. MMP7, a member of the matrix metalloproteinase family, is structurally different from the other matrix metalloproteinases by virtue of the absence of a conserved COOH-terminal protein domain. In addition, MMP7 mRNA is regulated in a specific and distinct manner in normal and malignant tissues. MMP7 has been shown to correlate with nodal or distant metastasis in colorectal carcinomas, however, its implication in early invasive colorectal carcinomas has not been determined. MMP7 is also a mediator of pulmonary fibrosis and a potential therapeutic target.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
Mouse partial recombinant protein (AA 95-264) was used as the immunogen for this MMP7 antibody.
Isotype
IgG
Predicted Reactivity
Mouse, Rat
Reactivity
Mouse, Rat
Recombinant
No
Gene Id
17393
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the MMP7 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Applications
WB, IHC-P, ELISA
Dilution
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml,ELISA: 0.1-0.5ug/ml