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Home / Primary Antibodies

MMP2 Antibody

SKU : BHA10559199

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA063238
Alternative Names	CLG4A; COLLAGENASE TYPE IV; 72-KD; COLLAGENASE TYPE IV-A; GELATINASE
Categories	Primary Antibodies
Clonality	polyclonal
Description	Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2:Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.Charlotte J. Morrison, J. Biol. Chem., Dec 2001; 276: 47402 - 47410. Hala S. Azzam, J Natl Cancer Inst, Nov 1993; 85: 1758 - 1764. Jane L. English, J. Biol. Chem., Apr 2006; 281: 10337 - 10346. JORDI ESPARZA, FASEB J, Nov 2004; 18: 1682 - 1691.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human MMP-2.
Involvement In Disease	Multicentric osteolysis, nodulosis, and arthropathy (MONA)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- ; -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2:Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways. Charlotte J. Morrison, J. Biol. Chem., Dec 2001; 276: 47402 - 47410. Hala S. Azzam, J Natl Cancer Inst, Nov 1993; 85: 1758 - 1764. Jane L. English, J. Biol. Chem., Apr 2006; 281: 10337 - 10346. JORDI ESPARZA, FASEB J, Nov 2004; 18: 1682 - 1691.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MMP-2 protein.
Subcellular Location	Isoform 1: Secreted, extracellular space, extracellular matrix, Membrane, Nucleus

Uniprot	P08253
Database Links	HGNC:7166 OMIM:120360 KEGG:hsa:4313 STRING:9606.ENSP00000219070 UniGene:Hs.513617
Function	Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- ; -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.; FUNCTION
Pathway	Estrogen signaling pathway Leukocyte transendothelial migration AGE-RAGE signaling pathway in diabetic complications
Protein Families	Peptidase M10A family
Tissue Specificity	Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559199	CSB-PA063238	100ul	$297		Add to Cart

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