Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.Michael H. Pillinger, J. Biol. Chem., May 2007; 10.1074Nick Di Girolamo, Invest. Ophthalmol. Vis. Sci., Nov 2003; 44: 4705. Eiji Sunami, Oncologist, Apr 2000; 5: 108. Christophe F. Deroanne, J. Cell Sci., Mar 2005; 118: 1173 - 1183.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human MMP-1 antibody., Synthesized peptide derived from Human MMP-1 antibody.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Michael H. Pillinger, J. Biol. Chem., May 2007; 10.1074 Nick Di Girolamo, Invest. Ophthalmol. Vis. Sci., Nov 2003; 44: 4705. Eiji Sunami, Oncologist, Apr 2000; 5: 108. Christophe F. Deroanne, J. Cell Sci., Mar 2005; 118: 1173 - 1183.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total MMP-1 protein.
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X
Pathway
PPAR signaling pathway IL-17 signaling pathway
Protein Families
Peptidase M10A family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen., The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.