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MLF1 Antibody

SKU : BHA10558508

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA583476
Alternative Names	Myeloid leukemia factor 1; Myelodysplasia-myeloid leukemia factor 1;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.Yoneda-Kato N., Oncogene 12:265-275(1996) [PubMed: 8570204].Hanissian S.H., Oncogene 23:3700-3707(2004) [PubMed: 15116101].Yoneda-Kato N., EMBO J. 24:1739-1749(2005) [PubMed: 15861129].
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human MLF1.
Involvement In Disease	A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. Yoneda-Kato N., Oncogene 12:265-275(1996) [PubMed: 8570204]. Hanissian S.H., Oncogene 23:3700-3707(2004) [PubMed: 15116101]. Yoneda-Kato N., EMBO J. 24:1739-1749(2005) [PubMed: 15861129].
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MLF1 protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	P58340
Database Links	HGNC:7125 OMIM:601402 KEGG:hsa:4291 UniGene:Hs.85195
Function	Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Protein Families	MLF family
Tissue Specificity	Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558508	CSB-PA583476	100ul	$297		Add to Cart

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