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Home / Primary Antibodies

MKNK1 (Ab-385) Antibody

SKU : BHA10559156

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA114367
Alternative Names	EC 2.7.11.1; kinase Mnk1; Map kinase interacting kinase; MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine kinase 1
Categories	Primary Antibodies
Clonality	polyclonal
Description	May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.Fukunaga R., EMBO J. 16:1921-1933(1997).Knauf U., Mol. Cell. Biol. 21:5500-5511(2001).O'Loghlen A., Exp. Cell Res. 299:343-355(2004).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human Mnk1 around the phosphorylation site of threonine 385 (L-P-T(p)-P-Q).
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Fukunaga R., EMBO J. 16:1921-1933(1997). Knauf U., Mol. Cell. Biol. 21:5500-5511(2001). O'Loghlen A., Exp. Cell Res. 299:343-355(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Mnk1 protein.
Subcellular Location	Isoform 2: Cytoplasm, SUBCELLULAR LOCATION: Isoform 3: Cytoplasm, Nucleus

Uniprot	Q9BUB5
Database Links	HGNC:7110 OMIM:606724 KEGG:hsa:8569 STRING:9606.ENSP00000361014 UniGene:Hs.371594
Function	May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
Pathway	HIF-1 signaling pathway MAPK signaling pathway MAPK Erk pathway Insulin signaling pathway
Protein Families	Protein kinase superfamily, CAMK Ser/Thr protein kinase family
Tissue Specificity	Ubiquitous.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559156	CSB-PA114367	100ul	$297		Add to Cart

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