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Home / Primary Antibodies

MKL1 Antibody

SKU : BHA10557997

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA091375
Alternative Names	Myocardin-related transcription factor A; MRTF-A; Megakaryoblastic leukemia 1 protein; Megakaryocytic acute leukemia protein;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation By similarity.Ma Z., Nat. Genet. 28:220-221(2001).Mercher T., Proc. Natl. Acad. Sci. U.S.A. 98:5776-5779(2001).Nagase T., DNA Res. 7:65-73(2000).
Host	Rabbit
Immunogen	Synthesized peptide derived from N-terminal of Human MKL1.
Involvement In Disease	A chromosomal aberration involving MKL1 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with RBM15. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation By similarity. Ma Z., Nat. Genet. 28:220-221(2001). Mercher T., Proc. Natl. Acad. Sci. U.S.A. 98:5776-5779(2001). Nagase T., DNA Res. 7:65-73(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MKL1 protein.
Subcellular Location	Nucleus, Cytoplasm

Uniprot	Q969V6
Database Links	HGNC:14334 OMIM:606078 KEGG:hsa:57591 STRING:9606.ENSP00000347847 UniGene:Hs.654688
Function	Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (By similarity).
Tissue Specificity	Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557997	CSB-PA091375	100ul	$297		Add to Cart

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