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Home / Primary Antibodies

MINK1 Antibody

SKU : BHA10557969

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA170472
Alternative Names	EC 2.7.11.1; Mitogen-activated protein kinase kinase kinase kinase 6; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6
Categories	Primary Antibodies
Clonality	polyclonal
Description	Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.Dan I., FEBS Lett. 469:19-23(2000).Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).Olsen J.V., Cell 127:635-648(2006).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human MAP4K6.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. Dan I., FEBS Lett. 469:19-23(2000). Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Olsen J.V., Cell 127:635-648(2006).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MAP4K6 protein.
Subcellular Location	Cytoplasm, Cell junction, synapse, postsynaptic cell membrane, postsynaptic density, Cell projection, axon, Cell projection, dendrite, SUBCELLULAR LOCATION: Isoform 4: Golgi apparatus

Uniprot	Q8N4C8
Database Links	HGNC:17565 OMIM:609426 KEGG:hsa:50488 STRING:9606.ENSP00000347427 UniGene:Hs.443417
Function	Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates
Protein Families	Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Tissue Specificity	Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas an

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557969	CSB-PA170472	100ul	$297		Add to Cart

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