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Home / Antibodies

MFGE8 Antibody (R31046)

SKU : BHA17104554

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NSJ Bioreagents

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Mfr.No.	R31046
Clonality	Polyclonal
Description	Milk Fat Globule-Egf Factor 8, also called Lactadherin or SED1, is a protein which in humans is encoded by the MFGE8 gene. It is a secreted protein found in vertebrates, including mammals as well as birds. By fluorescence in situ hybridization, Collins et al.(1997) mapped the gene to chromosome 15q25. Hanayama et al.(2002) found that it is a factor that links apoptotic cells to phagocytes. MFGE8 specifically bound to apoptotic cells by recognizing aminophospholipids such as phosphatidylserine. When engaged by phospholipids, it bound to cells via its RGD motif. It bound particularly strongly to cells expressing alpha-V-beta-3 integrin. Bu et al.(2007) showed that MFGE8 was expressed in intestinal lamina propria macrophages in mice. Using a wound-healing assay, they showed that the protein promoted migration of intestinal epithelial cells through a PKC-epsilon (PRKCE)-dependent mechanism.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the middle region of human MFGE8 (NGHEFDFIHDVNKKHK) was used as the immunogen for this MFGE8 antibody.
Isotype	IgG
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	Q08431

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the MFGE8 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB, IHC-P
Dilution	Weste blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104554	R31046	100 ug	$419		Add to Cart

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