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Home / Primary Antibodies

MET Antibody

BHA10557394
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
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Uniprot P08581
Database Links

HGNC:7029

OMIM:114550

KEGG:hsa:4233

STRING:9606.ENSP00000317272

UniGene:Hs.132966
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).
Pathway MAPK signaling pathway PI3K-Akt signaling pathway Focal adhesion Adherens junction Ras signaling pathway Rap1 signaling pathway
Protein Families Protein kinase superfamily, Tyr protein kinase family
Tissue Specificity Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also
Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format liquid
Purification Antigen Affinity Purified
Purity Antigen Affinity Purified
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Applications ELISA, WB, IF/ICC
Description ELISA ; WB ; IF/ICC, WB ; IF ; ICC ; ELISA
Dilution

WB1:500-1:2000
IF1:50-1:500
ICC1:50-1:500
Tested Application ELISA,WB,IF/ICC;WB:1:500-1:2000,IF/ICC:1:50-1:500
Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
SKU Supplier No. Size Your price Quantity
BHA10557394 CSB-PA933202 100ul $295
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