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Home / Primary Antibodies / Polyclonal Antibodies

MEK6 Antibody - SPC-1174

BHA11915930
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Contact us to order
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+1 866.986.9598
Email
[email protected]
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Swissprot P52564
Accession Number NP_002749
Gene Id 5608
Target MEK6
Research Area Cancer, Cell Cycle, Cell Cycle Inhibitors, Cell Signaling, Protein Phosphorylation, Tyrosine Kinases, Serine / Threonine Kinases, MAPK Pathway, Immunology, Innate Immunity, TLR Signaling
Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions WB (1:250); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Purity Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas.
Scientific Background Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.
Shipping Temperature Blue Ice or 4°C
Specificity Detects 37.492 kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, WB
Description WB ; AM
Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11915930-1 SPC-1174D Unconjugated 100 ul $331
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BHA11915930-2 SPC-1174D-A390 ATTO 390 100 ul $385
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BHA11915930-3 SPC-1174D-A488 ATTO 488 100 ul $384
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BHA11915930-4 SPC-1174D-A594 ATTO 594 100 ul $384
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BHA11915930-5 SPC-1174D-BI Biotin 100 ul $380
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BHA11915930-6 SPC-1174D-FITC FITC 100 ul $375
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