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Home / Primary Antibodies / Polyclonal Antibodies

MEK1 Antibody - SPC-1158

BHA11915660
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Ask Merchant
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Swissprot Q02750
Accession Number NP_002746
Gene Id 5604
Target MEK1
Research Area Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, MAPK Pathway, Tyrosine Kinases
Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions WB (1:250); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Purity Widely expressed, with extremely low levels in brain.
Scientific Background Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
Shipping Temperature Blue Ice or 4°C
Specificity Detects 43.308 kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, WB
Description WB ; AM
Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11915660-1 SPC-1158D Unconjugated 100 ul $331
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BHA11915660-2 SPC-1158D-A390 ATTO 390 100 ul $385
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BHA11915660-3 SPC-1158D-A488 ATTO 488 100 ul $384
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BHA11915660-4 SPC-1158D-A594 ATTO 594 100 ul $384
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BHA11915660-5 SPC-1158D-BI Biotin 100 ul $380
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BHA11915660-6 SPC-1158D-FITC FITC 100 ul $375
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