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Home / Primary Antibodies

MED8 Antibody

SKU : BHA10558479

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA991036
Alternative Names	Activator-recruited cofactor 32 kDa component; ARC32; MED8; Mediator complex subunit 8; Mediator of RNA polymerase II transcription subunit 8
Categories	Primary Antibodies
Clonality	polyclonal
Description	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.Brower C.S., Proc. Natl. Acad. Sci. U.S.A. 99:10353-10358(2002).Gregory S.G., Nature 441:315-321(2006).Naeaer A.M., Nature 398:828-832(1999).
Host	Rabbit
Immunogen	Synthesized peptide derived from Internal of Human MED8.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins. Brower C.S., Proc. Natl. Acad. Sci. U.S.A. 99:10353-10358(2002). Gregory S.G., Nature 441:315-321(2006). Naeaer A.M., Nature 398:828-832(1999).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MED8 protein.
Subcellular Location	Nucleus

Uniprot	Q96G25
Database Links	HGNC:19971 OMIM:607956 KEGG:hsa:112950 STRING:9606.ENSP00000290663 UniGene:Hs.301756
Function	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Families	Mediator complex subunit 8 family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558479	CSB-PA991036	100ul	$297		Add to Cart

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