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Home / Primary Antibodies

MeCP2 Antibody (phospho-S80) (F48587)

SKU : BHA17101281

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NSJ Bioreagents

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Mfr.No.	F48587, F48587-0.08ML, F48587-0.4ML
Antigen	Phospho-MeCP2
Clonality	Polyclonal
Description	DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	This phospho-MeCP2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS80 of human MeCP2.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	P51608

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	Aliquot the phospho-MeCP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	DB, ELISA
Dilution	Dot blot: 1:500

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17101281-1	F48587-0.08ML	0.08ml	$165		Add to Cart
BHA17101281-2	F48587-0.4ML	0.4ml	$389		Add to Cart

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