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Home / Antibodies

MECA-79 Antibody / Peripheral Node Addressin / PNAd (V8344SAF)

SKU : BHA17127419

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NSJ Bioreagents

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Mfr.No.	V8344SAF-100UG
Clonality	Monoclonal (rat origin)
Description	MECA-79 recognizes a carbohydrate epitope shared with a group of sulfation decorated sialomucins, including sulfated ligands for CD62L (CD34, GlyCAM-1, Sgp200, and a subset of MAdCAM-1). This set antigens has been referred to as peripheral node addressin (PNAd) with the molecular mass 50-250 kD. It has been identified that GlcNAc-6-SO4 sulfation contributes to MECA-79 binding and the core 1 beta1,3-N-acetylglucosaminyltransferase is required for the generation of the MECA-79 epitope. MECA-79 is expressed on high endothelial venules (HEV) of lymphoid tissues, chronic inflamed tissues and rheumatoid synovia. The interaction of PNAd with CD62L receptor is involved in tethering and rolling of lymphocytes along HEV in lymphoid tissues. MECA-79 antibody reacts with Mouse, human and many other species PNAd and blocks L-selectin-dependent lymphocyte adhesion in vitro and in vivo.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Rat
Immunogen Region	Mouse lymph node stromal cells were used as the immunogen for this MECA-79 antibody.
Isotype	Rat IgM, kappa
Species Reactivity	Human, Mouse, Rat
Note	Optimal dilution of the antibody should be determined by the researcher.

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the MECA-79 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	FACS, IF, WB, IHC-P
Description	Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml,Weste blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/meca-79-antibody-pnad-peripheral-node-addressin-meca-79-v8344" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17127419	V8344SAF-100UG	100 ug	$499		Add to Cart

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