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Home / Antibodies

MDM2 Antibody (phospho-T218) (F48546)

SKU : BHA17101266

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NSJ Bioreagents

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Mfr.No.	F48546, F48546-0.08ML, F48546-0.4ML
Clonality	Polyclonal
Description	MDM2 is a target of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle,apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5.
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	This p-MDM2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT218 of human MDM2.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	Q00987

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	Aliquot the p-MDM2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	DB, ELISA
Dilution	Dot blot: 1:500

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17101266-1	F48546-0.08ML	0.08ml	$165		Add to Cart
BHA17101266-2	F48546-0.4ML	0.4ml	$379		Add to Cart

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