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Home / Antibodies

MBTPS2 Antibody

SKU : BHA10558485

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA905280
Alternative Names	Membrane-bound transcription factor site-2 protease; EC 3.4.24.85; S2P endopeptidase; Site-2 protease; Sterol regulatory element-binding proteins intramembrane protease
Categories	Primary Antibodies
Clonality	polyclonal
Description	Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.Rawson R.B., Mol. Cell 1:47-57(1997).Ye J., Proc. Natl. Acad. Sci. U.S.A. 97:5123-5128(2000).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human MBTPS2.
Involvement In Disease	IFAP syndrome with or without BRESHECK syndrome (IFAPS); Olmsted syndrome, X-linked (OLMSX); Keratosis follicularis spinulosa decalvans X-linked (KFSDX)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop. Rawson R.B., Mol. Cell 1:47-57(1997). Ye J., Proc. Natl. Acad. Sci. U.S.A. 97:5123-5128(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MBTPS2 protein.
Subcellular Location	Membrane, Multi-pass membrane protein, Cytoplasm

Uniprot	O43462
Database Links	HGNC:15455 OMIM:300294 KEGG:hsa:51360 STRING:9606.ENSP00000368798 UniGene:Hs.443490
Function	Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.
Pathway	Protein processing in endoplasmic reticulum
Protein Families	Peptidase M50A family
Tissue Specificity	Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IF

Description

ELISA ; IF, IF ; ELISA

Dilution

IF	1:100-1:500

Tested Application

ELISA,IF;IF:1:100-1:500

Datasheet
ELISA Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558485	CSB-PA905280	100ul	$297		Add to Cart

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