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Home / Primary Antibodies / Polyclonal Antibodies

MBP Antibody - SPC-1301

BHA11917604
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+1 866.986.9598
Email
[email protected]
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Swissprot P02686
Accession Number NP_002376.1
Gene Id 4155
Target MBP
Research Area Cell Markers, Glial Markers, Oligodendrocytes Markers, Neuroscience
Buffer PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
Dilutions WB (1:1000); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Purity MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.
Scientific Background Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system. The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells.
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~19kDa and ~26kDa, endogenous level of total MBP(myelin basic protein) protein.
Storage -20ºC
Storage Buffer PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications WB
Description WB
Dilution WB (1:1000); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Sakamoto Y. et al. (1987) J. Biol. Chem. 262 (9): 4208–14.

2. Deber CM and Reynolds SJ. (1991) Clin. Biochem. 24 (2): 113–34.

3. Inouye H and Kirschner DA. (1991) J. Neurosci. Res. 28 (1): 1–17.

4. Eylar EH et al. (1971) J. Biol. Chem. 246 (18): 5770–84.

5. Berger T et al. (2003) N. Engl. J. Med. 349 (2): 139–45.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11917604-1 SPC-1301D Unconjugated 100 ul $286
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BHA11917604-2 SPC-1301D-A390 ATTO 390 100 ul $340
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BHA11917604-3 SPC-1301D-A488 ATTO 488 100 ul $339
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BHA11917604-4 SPC-1301D-A594 ATTO 594 100 ul $339
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BHA11917604-5 SPC-1301D-BI Biotin 100 ul $334
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BHA11917604-6 SPC-1301D-FITC FITC 100 ul $330
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