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Home / Antibodies

MBNL3 Antibody (V9208SAF)

SKU : BHA17123107

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NSJ Bioreagents

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Mfr.No.	V9208SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Several protein complexes are involved in proper mRNA splicing and transport. The muscleblind proteins, MBNL1, MBNL2 and MBNL3, promote inclusion or exclusion of specific exons on different pre-mRNAs by antagonizing the activity of CUG-BP and ETR-3-like factors bound to distinct intronic sites. MBNL1 and 2, which associate with expanded CUG repeats in vitro, localize to the nuclear foci in both DM1 and DM2 (myotonic dystrophy types 1 and 2), suggesting that the nuclear accumulation of mutant RNA is pathogenic in DM1, therefore implicating MBNL1 and 2 in the pathogenesis of both disorders. MBNL3, a 354 amino acid protein, inhibits expression of muscle differentiation, opposite to the function of MBNL1, which functions as a promoter of muscle differentiation. MBNL3 shows strong expression in placenta.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	Recombinant full-length human MBNL3 protein was used as the immunogen for the MBNL3 antibody.
Isotype	Mouse IgG2b
Species Reactivity	Human
Note	Optimal dilution of the MBNL3 antibody should be determined by the researcher.

Uniprot	Q9NUK0

Format	Purified
Purity	Protein A/G affinity
Storage	Aliquot the MBNL3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Applications	FACS
Description	Flow cytometry: 1-2ug/million cells

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17123107	V9208SAF-100UG	100ug	$499		Add to Cart

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