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Home / Primary Antibodies

MBD3 Antibody

SKU : BHA10557788

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA693569
Alternative Names	Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3; MBD3;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (). Recruits histone deacetylases and DNA methyltransferases.Hendrich B., Mol. Cell. Biol. 18:6538-6547(1998).Grimwood J., Nature 428:529-535(2004).Tatematsu K., Genes Cells 5:677-688(2000).
Host	Rabbit
Immunogen	Synthesized peptide derived from C-terminal of Human MBD3.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (). Recruits histone deacetylases and DNA methyltransferases. Hendrich B., Mol. Cell. Biol. 18:6538-6547(1998). Grimwood J., Nature 428:529-535(2004). Tatematsu K., Genes Cells 5:677-688(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MBD3 protein.
Subcellular Location	Nucleus, Chromosome

Uniprot	O95983
Database Links	HGNC:6918 OMIM:603573 KEGG:hsa:53615 STRING:9606.ENSP00000156825 UniGene:Hs.178728
Function	Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557788	CSB-PA693569	100ul	$297		Add to Cart

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