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Home / Primary Antibodies

MASTL Antibody

SKU : BHA10558003

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA901896
Alternative Names	Microtubule-associated serine/threonine-protein kinase-like; EC 2.7.11.1; THC2;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.Ota T., Nat. Genet. 36:40-45(2004).Deloukas P., Nature 429:375-381(2004).Beausoleil S.A., Nat. Biotechnol. 24:1285-1292(2006).
Host	Rabbit
Immunogen	Synthesized peptide derived from C-terminal of Human MASTL.
Involvement In Disease	Defects in MASTL may play a role in the pathogenesis of thrombocytopenia, a disorder defined by reduced number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. Ota T., Nat. Genet. 36:40-45(2004). Deloukas P., Nature 429:375-381(2004). Beausoleil S.A., Nat. Biotechnol. 24:1285-1292(2006).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MASTL protein.
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Nucleus, Cleavage furrow

Uniprot	Q96GX5
Database Links	HGNC:19042 OMIM:608221 KEGG:hsa:84930 STRING:9606.ENSP00000365107 UniGene:Hs.276905
Function	Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase
Protein Families	Protein kinase superfamily, AGC Ser/Thr protein kinase family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558003	CSB-PA901896	100ul	$297		Add to Cart

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