MACS; MARCS; PKCSL; PRKCSL; Protein kinase C substrate
Categories
Primary Antibodies
Clonality
polyclonal
Description
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.Pariser H, et al. Proc Natl Acad Sci U S A 2005 Aug 30; 102(35): 12407-12412Nagumo H, et al. Biochem Biophys Res Commun 2001 Jan 26; 280(3): 605-609Yamamoto H, et al. Arch Biochem Biophys 1998 Nov 15; 359(2): 151-159
Host
Rabbit
Immunogen
Peptide sequence around aa. 160~164 (K-K-S-F-K) derived from Human MARCKS.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
Pariser H, et al. Proc Natl Acad Sci U S A 2005 Aug 30; 102(35): 12407-12412 Nagumo H, et al. Biochem Biophys Res Commun 2001 Jan 26; 280(3): 605-609 Yamamoto H, et al. Arch Biochem Biophys 1998 Nov 15; 359(2): 151-159
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous level of total MARCKS protein.
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
Pathway
Fc gamma R-mediated phagocytosis
Protein Families
MARCKS family
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.