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Home / Primary Antibodies

MAPT (Ab-717/400) Antibody

SKU : BHA10557670

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA112612
Alternative Names	MAPT; Microtubule-associated protein tau; MTBT1; Neurofibrillary tangle protein; Paired helical filament-tau
Categories	Primary Antibodies
Clonality	polyclonal
Description	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.Goedert M.,Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988).Goedert M.,EMBO J. 8:393-399(1989).Lee G.,Neuron 2:1615-1624(1989).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human Tau around the phosphorylation site of serine 717/400 (V-V-S(p)-G-D).
Involvement In Disease	Frontotemporal dementia (FTD); Pick disease of the brain (PIDB); Progressive supranuclear palsy 1 (PSNP1); Parkinson-dementia syndrome (PARDE)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Goedert M.,Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988). Goedert M.,EMBO J. 8:393-399(1989). Lee G.,Neuron 2:1615-1624(1989).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Tau protein.
Subcellular Location	Cytoplasm, cytosol, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasm, cytoskeleton, Cell projection, axon

Uniprot	P10636
Database Links	HGNC:6893 OMIM:157140 KEGG:hsa:4137 STRING:9606.ENSP00000340820 UniGene:Hs.101174
Function	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Pathway	MAPK signaling pathway
Tissue Specificity	Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557670	CSB-PA112612	100ul	$297		Add to Cart

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