Rabbit Anti-Human MAPKAPK2 (pTyr225+pThr226) Polyclonal

Mfr.No.	SPC-1015, SPC-1015D, SPC-1015D-A390, SPC-1015D-A488, SPC-1015D-A594, SPC-1015D-BI, SPC-1015D-FITC
Immunogen Species	Human
Alternative Names	MAP kinase activated protein Kinase 2 antibody, MAPK2_HUMAN antibody, MAPKAP K2 antibody, MAPKAP kinase 2 antibody, MAPKAPK2 antibody, Mitogen activated protein kinase activated protein kinase 2 antibody, MK 2 antibody, MK2 antibody
Categories	Antibodies
Cellular Localization	Cytoplasmic
Certificate Of Analysis	A 1:250 dilution of SPC-1015 was sufficient for detection of MAPKAPK2 (pTyr225+pThr226) in 10 ug of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human MAPKAPK2 (pTyr225+pThr226) Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	A phospho-specific peptide corresponding to residues surrounding Tyr225 and Thr226 of human MAPKAPK2 (AA223-230), Homo Sapiens (Human)
Immunogen Region	A phospho-specific peptide corresponding to residues surrounding Tyr225 and Thr226 of human MAPKAPK2 (AA223-230)
Launch Date	2016/08/29
Net Weight (g)	0.1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human
Tissue Specificity	Expressed in all tissues examined.

Swissprot	P49137
Accession Number	NP_116584
Gene Id	9261
Target	MAPKAPK2 (pTyr225+pThr226)
Research Area	Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, MAPK Pathway, Microfilaments, Actin, Cardiovascular System, Blood, Cytoskeleton

Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions	WB (1:250); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Purity	Expressed in all tissues examined.
Scientific Background	MAPKAPK2 is a protein-serine/threonine kinase regulated through direct phosphorylation by p38 MAPK. It is involved in a number of cellular processes such as inflammation, stress responses, nuclear export, cell proliferation, and regulation of gene expression. It mediates both ERK and p38 MAPK-dependent neutrophil responses, participates in TNFalpha-stimulated exocytosis of secretory vesicles in neutrophils, and plays a role in phagocytosis-induced respiratory burst activity. Another one of its major substrates is HSP27, a protein responsble for stimulating actin polymerization in order to facilitate the recovery from cytoskeleton destruction during cellular stress. Over-expression of the gene has been linked to Multiple Myeloma resistance to chemotherapy, and it has been found to play a role in neuroinflammatory and neurodegenerative diseases such as Alzheimer's.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects 45.568 kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, WB
Description	WB ; AM
Dilution	WB (1:250); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11913086-1	SPC-1015D	Unconjugated	100 ul	$331	Add to Cart
BHA11913086-2	SPC-1015D-A390	ATTO 390	100 ul	$385	Add to Cart
BHA11913086-3	SPC-1015D-A488	ATTO 488	100 ul	$384	Add to Cart
BHA11913086-4	SPC-1015D-A594	ATTO 594	100 ul	$384	Add to Cart
BHA11913086-5	SPC-1015D-BI	Biotin	100 ul	$380	Add to Cart
BHA11913086-6	SPC-1015D-FITC	FITC	100 ul	$375	Add to Cart

MAPKAPK2 Antibody (pTyr225+pThr226) - SPC-1015