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Home / Primary Antibodies

MAPKAPK2 (Ab-334) Antibody

SKU : BHA10559054

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA550963
Alternative Names	MAP kinase-activated protein kinase 2
Categories	Primary Antibodies
Clonality	polyclonal
Description	MAPKAPK-2 encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through directphosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.Rouse, J. et al. (1994) Cell 78, 1027-1037.Ben-Levy, R. et al. (1995) EMBO J. 14, 5920-5930.
Host	Rabbit
Immunogen	Peptide sequence around aa.332~336 (P-Q-T-P-L) derived from Human MAPKAPK-2.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	MAPKAPK-2 encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through directphosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. Rouse, J. et al. (1994) Cell 78, 1027-1037. Ben-Levy, R. et al. (1995) EMBO J. 14, 5920-5930.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total MAPKAPK-2 protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	P49137
Database Links	HGNC:6887 OMIM:602006 KEGG:hsa:9261 STRING:9606.ENSP00000356070 UniGene:Hs.643566
Function	Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities
Pathway	MAPK signaling pathway VEGF signaling pathway Cellular senescence Neurotrophin signaling pathway
Protein Families	Protein kinase superfamily, CAMK Ser/Thr protein kinase family
Tissue Specificity	Expressed in all tissues examined.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:1000
IF	1:100-1:200

Tested Application

ELISA,WB,IF;WB:1:500-1:1000,IF:1:100-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559054	CSB-PA550963	100ul	$297		Add to Cart

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