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Home / Primary Antibodies

MAP4K4 Antibody

SKU : BHA10559257

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA781476
Alternative Names	EC 2.7.11.1; HPK/GCK-like kinase HGK; M4K4; MAP4K4; MAPK/ERK kinase kinase kinase 4
Categories	Primary Antibodies
Clonality	polyclonal
Description	Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.Yao Z., J. Biol. Chem. 274:2118-2125(1999).Wright J.H., Mol. Cell. Biol. 23:2068-2082(2003).Ishikawa K., DNA Res. 5:169-176(1998).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human MEKKK 4.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. Yao Z., J. Biol. Chem. 274:2118-2125(1999). Wright J.H., Mol. Cell. Biol. 23:2068-2082(2003). Ishikawa K., DNA Res. 5:169-176(1998).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MEKKK 4 protein.
Subcellular Location	Cytoplasm

Uniprot	O95819
Database Links	HGNC:6866 OMIM:604666 KEGG:hsa:9448 STRING:9606.ENSP00000314363 UniGene:Hs.701013
Function	Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.
Pathway	MAPK signaling pathway
Protein Families	Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Tissue Specificity	Widely expressed. Isoform 5 is abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559257	CSB-PA781476	100ul	$297		Add to Cart

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