Rabbit Anti-Human MAP3K8 (pSer334) Polyclonal

Mfr.No.	SPC-953, SPC-953D, SPC-953D-A390, SPC-953D-A488, SPC-953D-A594, SPC-953D-BI, SPC-953D-FITC
Immunogen Species	Human
Alternative Names	Cancer Osaka thyroid oncogene Antibody, CCOT Antibody, COT Antibody, EST Antibody, Ewing sarcoma transformant Antibody, M3K8_HUMAN Antibody, MEKK8 Antibody, Mitogen activated protein kinase kinase kinase 8 Antibody, Serine/threonine protein kinase cot Antibody, TPL 2 Antibody, Tumor progression locus 2 Antibody
Categories	Antibodies
Cellular Localization	Cytoplasm
Certificate Of Analysis	A 1:250 dilution of SPC-953 was sufficient for detection of MAP3K8 (pSer334) in 10 ug of 293T cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human MAP3K8 (pSer334) Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	A phospho-specific peptide corresponding to residues surrounding Ser334 of human COT (AA331-337), Homo Sapiens (Human)
Immunogen Region	A phospho-specific peptide corresponding to residues surrounding Ser334 of human COT (AA331-337)
Launch Date	2016/08/29
Net Weight (g)	0.1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human
Tissue Specificity	Expressed in several normal tissues and human tumor-derived cell lines.

Swissprot	P41279
Accession Number	NP_005195
Gene Id	1326
Target	MAP3K8 (pSer334)
Research Area	Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, MAPK Pathway, Cancer

Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions	WB (1:250); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Purity	Expressed in several normal tissues and human tumor-derived cell lines.
Scientific Background	MAP3K8 is a protein serine/threonine kinase that can activate both MAPK and JNKK pathways. It is required for TLR4 activation of the MEK/ERK pathway. It can activate NF-kB1 by stimulating the proteolysis of its inhibitor, p105, and promote the production of TNF-alpha and IL-2 during T-cell activation. It has been shown to mediate Raf-inhibiting drug resistance in BRAF(V600E) cell lines. MAP3K8 may also play a role in the cell cycle.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects 52.898 kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, WB
Description	WB ; AM
Dilution	WB (1:250); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11911970-1	SPC-953D	Unconjugated	100 ul	$331	Add to Cart
BHA11911970-2	SPC-953D-A390	ATTO 390	100 ul	$385	Add to Cart
BHA11911970-3	SPC-953D-A488	ATTO 488	100 ul	$384	Add to Cart
BHA11911970-4	SPC-953D-A594	ATTO 594	100 ul	$384	Add to Cart
BHA11911970-5	SPC-953D-BI	Biotin	100 ul	$380	Add to Cart
BHA11911970-6	SPC-953D-FITC	FITC	100 ul	$375	Add to Cart

MAP3K8 Antibody (pSer334) - SPC-953