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Home / Antibodies

MAP3K13 Antibody

SKU : BHA10557759

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA029472
Alternative Names	Mitogen-activated protein kinase kinase kinase 13; EC 2.7.11.25; Mixed lineage kinase; MLK; Leucine zipper-bearing kinase
Categories	Primary Antibodies
Clonality	polyclonal
Description	Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.Sakuma H., J. Biol. Chem. 272:28622-28629(1997).Schultz S.J., Cell Growth Differ. 4:821-830(1993).Ikeda A., FEBS Lett. 488:190-195(2001).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human M3K13.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. Sakuma H., J. Biol. Chem. 272:28622-28629(1997). Schultz S.J., Cell Growth Differ. 4:821-830(1993). Ikeda A., FEBS Lett. 488:190-195(2001).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total M3K13 protein.
Subcellular Location	Cytoplasm, Membrane, Peripheral membrane protein

Uniprot	O43283
Database Links	HGNC:6852 OMIM:604915 KEGG:hsa:9175 STRING:9606.ENSP00000265026 UniGene:Hs.591306
Function	Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.
Pathway	MAPK signaling pathway
Protein Families	Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
Tissue Specificity	Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557759	CSB-PA029472	100ul	$297		Add to Cart

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