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Home / Primary Antibodies

MAN1B1 Antibody

SKU : BHA10558401

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA217897
Alternative Names	Endoplasmic reticulum mannosyl-oligosaccharide 1; 2-alpha-mannosidase; EC=3.2.1.113; ER alpha-1; 2-mannosidase
Categories	Primary Antibodies
Clonality	polyclonal
Description	Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2, but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man5-6GlcNAc2.Tremblay L.O., Glycobiology 9:1073-1078(1999) [PubMed: 10521544].Gonzalez D.S., J. Biol. Chem. 274:21375-21386(1999) [PubMed: 10409699].Clark H.F., Genome Res. 13:2265-2270(2003) [PubMed: 12975309].
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human MAN1B1.
Involvement In Disease	Mental retardation, autosomal recessive 15 (MRT15)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2, but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man5-6GlcNAc2. Tremblay L.O., Glycobiology 9:1073-1078(1999) [PubMed: 10521544]. Gonzalez D.S., J. Biol. Chem. 274:21375-21386(1999) [PubMed: 10409699]. Clark H.F., Genome Res. 13:2265-2270(2003) [PubMed: 12975309].
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MAN1B1 protein.
Subcellular Location	Endoplasmic reticulum membrane, Single-pass type II membrane protein

Uniprot	Q9UKM7
Database Links	HGNC:6823 OMIM:604346 KEGG:hsa:11253 STRING:9606.ENSP00000360645 UniGene:Hs.279881
Function	Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2).
Pathway	Protein processing in endoplasmic reticulum
Protein Families	Glycosyl hydrolase 47 family
Tissue Specificity	Widely expressed.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558401	CSB-PA217897	100ul	$297		Add to Cart

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