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Home / Antibodies

MAK (Ab-159) Antibody

SKU : BHA10557676

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA056397
Alternative Names	EC 2.7.11.22; Male germ cell-associated kinase; Serine/threonine-protein kinase MAK;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors By similarity. Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.Mungall A.J., Nature 425:805-811(2003).Matsushime H., Mol. Cell. Biol. 10:2261-2268(1990).Greenman C., Nature 446:153-158(2007).
Host	Rabbit
Immunogen	Synthesized peptide derived from Internal of Human MAK.
Involvement In Disease	Retinitis pigmentosa 62 (RP62)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors By similarity. Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. Mungall A.J., Nature 425:805-811(2003). Matsushime H., Mol. Cell. Biol. 10:2261-2268(1990). Greenman C., Nature 446:153-158(2007).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MAK protein.
Subcellular Location	Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, spindle, Midbody, Cell projection, cilium, photoreceptor outer segment, Photoreceptor inner segment

Uniprot	P20794
Database Links	HGNC:6816 OMIM:154235 KEGG:hsa:4117 STRING:9606.ENSP00000313021 UniGene:Hs.446125
Function	Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.
Protein Families	Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Tissue Specificity	Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photo

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557676	CSB-PA056397	100ul	$297		Add to Cart

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