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Home / Primary Antibodies

MAGI2 Antibody

SKU : BHA10557964

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA213488
Alternative Names	Atrophin-1 interacting protein 1; Atrophin-1 interacting protein A; KIAA0705; MAGI-2; MAGI2
Categories	Primary Antibodies
Clonality	polyclonal
Description	Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.Florindo C.S., Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. The MGC Project Team, Genome Res. 14:2121-2127(2004). Devroe E., J. Biol. Chem. 279:24444-24451(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human MAGI2.
Involvement In Disease	Nephrotic syndrome 15 (NPHS15)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. Florindo C.S., Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. The MGC Project Team, Genome Res. 14:2121-2127(2004). Devroe E., J. Biol. Chem. 279:24444-24451(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MAGI2 protein.
Subcellular Location	Cytoplasm, Late endosome, Cell junction, synapse, synaptosome, Cell membrane, Peripheral membrane protein

Uniprot	Q86UL8
Gene Id	9863
Database Links	HGNC:18957 OMIM:606382 KEGG:hsa:9863 STRING:9606.ENSP00000346151 UniGene:Hs.603842
Function	Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.
Pathway	Rap1 signaling pathway
Protein Families	MAGUK family
Tissue Specificity	Specifically expressed in brain.
Weight	157,236 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557964	CSB-PA213488	100ul	$297		Add to Cart

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