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MAGEC2 Antibody

SKU : BHA10558866

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA574003
Alternative Names	Cancer/testis antigen 10; CT10; HCA587; hepatocellular cancer antigen 587; Hepatocellular carcinoma-associated antigen 587
Categories	Primary Antibodies
Clonality	polyclonal
Description	Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.Gure A.O., Int. J. Cancer 85:726-732(2000) [PubMed: 10699956].Lucas S., Int. J. Cancer 87:55-60(2000) [PubMed: 10861452].Wang Y., J. Immunol. 169:1102-1109(2002) [PubMed: 12097419].
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human MAGEC2.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. Gure A.O., Int. J. Cancer 85:726-732(2000) [PubMed: 10699956]. Lucas S., Int. J. Cancer 87:55-60(2000) [PubMed: 10861452]. Wang Y., J. Immunol. 169:1102-1109(2002) [PubMed: 12097419].
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MAGEC2 protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	Q9UBF1
Database Links	HGNC:13574 OMIM:300468 KEGG:hsa:51438 STRING:9606.ENSP00000354660 UniGene:Hs.123536
Function	Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3
Tissue Specificity	Not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non-small cell lung c

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558866	CSB-PA574003	100ul	$297		Add to Cart

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